Castellaniella has a medical presentation much like fowl cholera
6 August 2024
2 minute learn
[Excerpts of a presentation
by Tiffani Allen, Yi-Chen Luo, Jenny Nicholds, and Grazieli Maboni, Poultry Diagnostic and
Research Center, University of Georgia, during the 2024 conference of the
American Association of Avian Pathologists]
Castellaniella is a Gram-negative bacterium generally remoted from
soil. Earlier than 2015, Castellaniella had not been related to mortality
in animals till reported as a causative agent of suppurative inflammatory
illness in rabbits. Starting in 2018, the Poultry Diagnostic and Analysis
Heart (PDRC), College of Georgia, repeatedly remoted Castellaniella
from 19 instances in business broiler breeders. In all instances, a mix of
swollen wattles, lameness, and/or mortality had been noticed, presenting equally
to power fowl cholera attributable to Pasteurella multocida. Regardless of this
medical presentation, isolates had been recognized as Castellaniella spp.
Previous to this research, no instances
of Castellaniella had been documented in any poultry species. The aim of this research was
to offer a complete phenotypic characterization of Castellaniella
related to medical illness in chickens.
Excessive MIC (minimal inhibitory
concentrations) values had been obtained for antibiotics: Ceftiofur (18/18, MIC
≥4), clindamycin (18/18, MIC >4), erythromycin (18/18, MIC >4),
novobiocin (18/18, MIC >4), penicillin (18/18, MIC ≥8), and tylosin (18/18,
MIC >20), indicating antimicrobial resistance. Low MIC values had been obtained
for enrofloxacin (17/18, MIC ≤0.25), florfenicol (18/18, MIC ≤1), neomycin
18/18, MIC<2), spectinomycin (17/18, MIC ≤16), and tetracycline (18/18, MIC
≤4), indicating antimicrobial susceptibility.
That is the primary identified research
documenting antimicrobial susceptibility profiles from medical avian isolates.
Primarily based on this knowledge, tetracyclines are really helpful in therapy of medical
instances whereas penicillin ought to be averted on account of a possible mechanism of
intrinsic resistance. With the emergence of drug resistant micro organism in
veterinary drugs, elevated stress has arisen to lower antimicrobial
use.
